Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | IDH2 | P48735 | 2/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165886 | 1.00 | SCN9A (0.46) | SCN9AIDH2ALOX5APFEN1TSHR | |
| SCHEMBL5178711 | 1.00 | SCN9A (0.46) | SCN9AIDH2ALOX5APFEN1TSHR | |
| SCHEMBL5064822 | 0.93 | SCN9A (0.48) | SCN9AIDH2ALOX5APFEN1TSHR | |
| SCHEMBL13397358 | 0.91 | SCN9A (0.47) | SCN9AALOX5APFEN1CHEK2GLS | |
| SCHEMBL2031191 | 0.91 | SCN9A (0.47) | SCN9AALOX5APFEN1CHEK2GLS | |
| SCHEMBL5164315 | 0.88 | IDH2 (0.46) | IDH2TSHRCYP2C9CHEK1 | |
| SCHEMBL5066850 | 0.87 | SCN9A (0.48) | SCN9AIDH2ALOX5APFEN1CHEK2 | |
| SCHEMBL5163065 | 0.80 | CHEK1 (0.49) | SCN9AIDH2TSHRCYP2C9CHEK1 | |
| SCHEMBL5163178 | 0.80 | CHEK1 (0.49) | SCN9AIDH2TSHRCYP2C9CHEK1 | |
| SCHEMBL5163078 | 0.80 | CHEK1 (0.49) | SCN9AIDH2TSHRCYP2C9CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765808-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006012308-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |