Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.37 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.37 |
| ▸ | RPS17 | P08708 | 1/20 | 0.37 |
| ▸ | RPSA | P08865 | 1/20 | 0.37 |
| ▸ | RPS2 | P15880 | 1/20 | 0.37 |
| ▸ | RPL35A | P18077 | 1/20 | 0.37 |
| ▸ | RPL7 | P18124 | 1/20 | 0.37 |
| ▸ | RPL17 | P18621 | 1/20 | 0.37 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.37 |
| ▸ | RPS3 | P23396 | 1/20 | 0.37 |
| ▸ | RPS12 | P25398 | 1/20 | 0.37 |
| ▸ | RPL13 | P26373 | 1/20 | 0.37 |
| ▸ | RPL10 | P27635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166973 | 0.89 | IKBKB (0.40) | PRKCICDK2IKBKBCHUKABL1 | |
| SCHEMBL5164173 | 0.88 | CHEK1 (0.44) | PRKCICDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL5164962 | 0.88 | IKBKB (0.38) | PRKCICDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL5166876 | 0.86 | PRKCI (0.38) | PRKCICDK2CCNT1CCNE1CDK9 | |
| SCHEMBL5165078 | 0.85 | IKBKB (0.36) | PRKCICDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL5166766 | 0.85 | IKBKB (0.36) | PRKCICDK2CHEK1GSK3BDYRK1A | |
| SCHEMBL5166222 | 0.85 | IKBKB (0.42) | CDK2CHEK1CCNA2CCNA1HDAC1 | |
| SCHEMBL5164348 | 0.84 | IKBKB (0.36) | PRKCICDK2CHEK1IKBKBCHUK | |
| SCHEMBL5166332 | 0.84 | IKBKB (0.38) | PRKCICDK2CHEK1IKBKBCHUK | |
| SCHEMBL5166226 | 0.84 | IKBKB (0.37) | PRKCICDK2IKBKBCHUKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | PFIZER INC. | 2007-09-27 | — | — | US | claimed |
| EP-1678164-B1 | SUBSTITUTED PYRAZINONE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORP (US) | 2007-04-11 | — | — | EP | claimed |
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | PFIZER INC. | 2007-09-27 | — | — | US | disclosed |
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | PFIZER INC. | 2007-09-27 | — | — | US | disclosed |
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | PFIZER INC. | 2007-09-27 | — | — | US | disclosed |
| EP-1678164-B1 | SUBSTITUTED PYRAZINONE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORP (US) | 2007-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225291-A1 | Substituted Pyrazinone Compounds for the Treatment of Inflammation | CNKSR1, IL1RN, CHUK | PRKCI 1363/4885CDK2 159/4885CHEK1 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.