Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 8/20 | 1.00 |
| ▸ | AR | P10275 | 8/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.65 |
| ▸ | SHBG | P04278 | 2/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166591 | 1.00 | ESR1 (1.00) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL14430121 | 1.00 | ESR1 (1.00) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL11517173 | 0.88 | ESR1 (0.78) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL3362181 | 0.88 | ESR1 (0.78) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL28502819 | 0.84 | AR (0.73) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL5169496 | 0.83 | ESR1 (0.71) | ESR1ESR2ARCYP19A1 | |
| SCHEMBL9782693 | 0.83 | SRD5A2 (0.74) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL14430123 | 0.83 | ESR1 (0.71) | ESR1ESR2ARCYP19A1 | |
| SCHEMBL9782697 | 0.83 | SRD5A2 (0.74) | ESR1ESR2ARCYP19A1SHBG | |
| SCHEMBL9117868 | 0.83 | SRD5A2 (0.74) | ESR1ESR2ARCYP19A1SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203102-A1 | Estrogen Receptor Modulators | MERCK & CO., INC. | 2007-08-30 | — | — | US | disclosed |
| EP-1773862-A1 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012333-A1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203102-A1 | Estrogen Receptor Modulators | ESR2, GPER1, ESRRA | ESR1 5/4885ESR2 1/4885AR 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.