Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | PGK2 | P07205 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | PTPRB | P23467 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166721 | 0.85 | PTPN1 (0.36) | PYCR1PTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL5165292 | 0.82 | PTPN5 (0.44) | PTPN1 | |
| SCHEMBL7598722 | 0.81 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL14076471 | 0.81 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7182139 | 0.81 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL5162409 | 0.81 | PTPN1 (0.39) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL5179142 | 0.80 | HDAC1 (0.51) | PTPN1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL24984756 | 0.79 | MAPT (0.41) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL5167139 | 0.79 | HDAC3 (0.52) | PTPN1PTPN2PTPN6PTPN11MEN1 | |
| Hydrochloric Acid SCHEMBL5165752 | 0.79 | PTPN1 (0.41) | PTPN1PTPN2PTPN6PTPN11PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | PYCR1 323/4885PTPN1 2/4885PTPN2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.