Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490150 | 0.87 | MAPT (0.42) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4470722 | 0.86 | NPY1R (0.43) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4480565 | 0.86 | MGMT (0.43) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4479923 | 0.84 | MAPT (0.39) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5165782 | 0.84 | MAPT (0.39) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4489265 | 0.84 | SMN1; SMN2 (0.40) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4475566 | 0.83 | MAPT (0.60) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4482733 | 0.82 | MAPT (0.37) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4481037 | 0.82 | MAPT (0.42) | MAPTLMNAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4473465 | 0.81 | MAPT (0.47) | MAPTLMNAALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765791-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006014482-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |