Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 1/20 | 0.57 |
| ▸ | FRK | P42685 | 1/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.57 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.57 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.57 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.57 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.57 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276164 | 0.88 | FLT3 (0.65) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL327935 | 0.81 | FLT3 (0.65) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL276055 | 0.81 | FLT3 (0.58) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL275553 | 0.79 | FLT3 (0.70) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL277296 | 0.77 | FLT3 (0.81) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL275725 | 0.77 | FLT3 (0.68) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL275566 | 0.77 | FLT3 (0.71) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL275765 | 0.77 | FLT3 (0.69) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL276291 | 0.76 | FLT3 (0.67) | FGFR1FLT3RETBCRFRK | |
| SCHEMBL276543 | 0.76 | FLT3 (0.68) | FGFR1FLT3RETBCRFRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957077-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer HealthCare LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064883-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC. (US) | 2007-06-07 | — | — | WO | claimed |