Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.74 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.68 |
| ▸ | PLK1 | P53350 | 2/20 | 0.55 |
| ▸ | IGF1R | P08069 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517613 | 0.92 | EGFR (0.75) | EGFRALKPLK1IGF1RAURKA | |
| SCHEMBL517301 | 0.91 | EGFR (0.72) | EGFRALKPLK1IGF1RAURKA | |
| SCHEMBL518394 | 0.91 | ALK (0.83) | EGFRALKIGF1RAURKAINSR | |
| SCHEMBL517907 | 0.91 | ALK (0.83) | EGFRALKIGF1RCDK2DYRK1B | |
| SCHEMBL517477 | 0.87 | EGFR (0.84) | EGFRALKIGF1RINSR | |
| Trifluoroacetic Acid SCHEMBL517839 | 0.85 | ALK (0.73) | EGFRALKIGF1RCDK2DYRK1B | |
| SCHEMBL517390 | 0.82 | ALK (0.84) | EGFRALKIGF1RCDK2DYRK1B | |
| SCHEMBL517412 | 0.81 | ALK (1.00) | EGFRALKIGF1R | |
| SCHEMBL517332 | 0.81 | ALK (0.70) | EGFRALKIGF1RCDK2DYRK1B | |
| SCHEMBL29355191 | 0.81 | ALK (1.00) | EGFRALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| US-8461170-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2013-06-11 | — | — | US | disclosed |
| US-8461170-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2013-06-11 | — | — | US | disclosed |
| US-8461170-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2013-06-11 | — | — | US | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-02 | — | — | US | disclosed |
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-02 | — | — | US | disclosed |
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028924-A1 | CHEMICAL COMPOUNDS | ALK, BRAF, ABL1 | EGFR 40/4885ALK 1/4885PLK1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.