Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ1 | P51787 | 6/20 | 0.57 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.54 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.47 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171521 | 0.97 | KCNQ1 (0.60) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL630691 | 0.97 | KCNQ1 (0.60) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL630690 | 0.97 | KCNQ1 (0.60) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL5171150 | 0.90 | KCNQ1 (0.55) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL629837 | 0.90 | KCNQ1 (0.62) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL629838 | 0.90 | KCNQ1 (0.62) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL5173103 | 0.90 | KCNQ1 (0.62) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL630250 | 0.89 | ITGB1 (0.55) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL630254 | 0.89 | ITGB1 (0.55) | KCNQ1ITGB1ITGA4ITGB7ITGA5 | |
| SCHEMBL630255 | 0.89 | ITGB1 (0.55) | KCNQ1ITGB1ITGA4ITGB7ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |