⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173856 | 1.00 | — | — | |
| SCHEMBL7594243 | 1.00 | — | — | |
| SCHEMBL5174827 | 0.83 | — | — | |
| SCHEMBL7595320 | 0.83 | — | — | |
| SCHEMBL5172995 | 0.83 | — | — | |
| SCHEMBL5174053 | 0.83 | CYP1A2 (0.41) | — | |
| SCHEMBL5173527 | 0.83 | CYP1A2 (0.41) | — | |
| SCHEMBL7599183 | 0.81 | AKT1 (0.53) | — | |
| SCHEMBL7595669 | 0.81 | AKT1 (0.53) | — | |
| SCHEMBL5173836 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257535-B1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2007-05-23 | — | — | EP | claimed |
| US-6656958-B2 | Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers; selectively controlling neurotransmitter release in mammals using these compounds | ABBOTT LABORATORIES | 2003-12-02 | — | — | US | claimed |
| US-20020058646-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBVIE INC. | 2002-05-16 | — | — | US | claimed |
| US-20010034357-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBOTT LABORATORIES | 2001-10-25 | — | — | US | claimed |
| EP-1257535-B1 | SUBSTITUTED PYRIDINE COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2007-05-23 | — | — | EP | disclosed |
| US-6656958-B2 | Preferred compounds are 3'-(5'- and/or 6'-substituted) pyridyl ethers; selectively controlling neurotransmitter release in mammals using these compounds | ABBOTT LABORATORIES | 2003-12-02 | — | — | US | disclosed |
| US-20020058646-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBVIE INC. | 2002-05-16 | — | — | US | disclosed |
| US-20010034357-A1 | Substituted pyridine compounds useful for controlling chemical synaptic transmission | ABBOTT LABORATORIES | 2001-10-25 | — | — | US | disclosed |