Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471665 | 0.95 | BRAF (0.50) | BRAFABL1BCR | |
| Pivalamide SCHEMBL5175771 | 0.93 | BRAF (0.47) | BRAFABL1BCR | |
| SCHEMBL5176650 | 0.89 | BRAF (0.45) | BRAF | |
| SCHEMBL4477561 | 0.89 | BRAF (0.52) | BRAF | |
| SCHEMBL5175774 | 0.89 | BRAF (0.47) | BRAFABL1BCR | |
| SCHEMBL5177542 | 0.88 | BRAF (0.40) | BRAF | |
| SCHEMBL5177016 | 0.87 | BRAF (0.48) | BRAF | |
| SCHEMBL5179484 | 0.85 | ABL1 (0.38) | BRAFABL1BCR | |
| SCHEMBL5179150 | 0.85 | BRAF (0.46) | BRAF | |
| SCHEMBL5177001 | 0.84 | BRAF (0.48) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756065-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115991-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |