Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735423 | 0.83 | C1S (0.50) | C1SPARP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8282535 | 0.83 | C1S (0.50) | C1SPARP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5735430 | 0.83 | C1S (0.50) | C1SPARP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1984244 | 0.78 | C1S (0.46) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL1984246 | 0.78 | C1S (0.46) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL15587046 | 0.78 | C1S (0.46) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL4143291 | 0.78 | PARP1 (0.50) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL4143287 | 0.78 | PARP1 (0.50) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL4143293 | 0.78 | PARP1 (0.50) | C1SPARP1ALDH1A1L3MBTL1TP53 | |
| SCHEMBL2792142 | 0.77 | C1S (0.48) | C1SPARP1ALDH1A1L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |