Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.39 |
| ▸ | BCR | P11274 | 8/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343329 | 1.00 | ABL1 (0.39) | ABL1BCRMAPK11MAPK14PPARG | |
| SCHEMBL4479189 | 0.95 | ABL1 (0.42) | ABL1BCRMAPK11MAPK14PPARG | |
| SCHEMBL4463276 | 0.95 | ABL1 (0.42) | ABL1BCRMAPK11MAPK14PPARG | |
| SCHEMBL4463281 | 0.95 | ABL1 (0.42) | ABL1BCRMAPK11MAPK14PPARG | |
| SCHEMBL13935950 | 0.88 | ABL1 (0.39) | ABL1BCRMAPK11MAPK14BRAF | |
| SCHEMBL13935942 | 0.88 | ABL1 (0.39) | ABL1BCRMAPK11MAPK14BRAF | |
| SCHEMBL5177343 | 0.88 | ABL1 (0.39) | ABL1BCRMAPK11MAPK14BRAF | |
| SCHEMBL5177289 | 0.85 | MAPK11 (0.40) | ABL1BCRMAPK11MAPK14PPARG | |
| SCHEMBL5179173 | 0.83 | HTT (0.37) | ABL1PPARGNR1H4HPGDHTT | |
| SCHEMBL5179484 | 0.81 | ABL1 (0.38) | ABL1BCRMAPK11MAPK14PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756065-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115991-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |