Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 10/20 | 0.51 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 3/20 | 0.45 |
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561228 | 0.91 | CHEK2 (0.61) | CHEK2KMT2A | |
| SCHEMBL3571326 | 0.84 | CHEK2 (0.67) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL5177752 | 0.82 | CHEK2 (0.45) | CHEK2PRSS12KMT2ASCD | |
| SCHEMBL28930292 | 0.80 | KDM4E (0.68) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3567770 | 0.80 | CHEK2 (0.66) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL11563729 | 0.79 | CHEK2 (0.78) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL7602620 | 0.79 | KDM4E (0.70) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3863014 | 0.78 | CSNK2A2 (0.49) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3918744 | 0.78 | CHEK2 (0.80) | CHEK2NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3568288 | 0.78 | CHEK2 (0.72) | CHEK2NR4A2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-B1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5]-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-06 | — | — | EP | claimed |