Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5676245 | 0.94 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL1379297 | 0.92 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL1381793 | 0.86 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL5675973 | 0.83 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL3565315 | 0.83 | CHEK2 (0.71) | CHEK2 | |
| SCHEMBL5676214 | 0.82 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL1380924 | 0.81 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL5680491 | 0.81 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL1382147 | 0.81 | CHEK2 (0.73) | CHEK2 | |
| SCHEMBL5177920 | 0.80 | CHEK2 (0.66) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-B1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5]-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-06 | — | — | EP | claimed |