Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.70 |
| ▸ | FLT3 | P36888 | 10/20 | 0.70 |
| ▸ | FLT4 | P35916 | 9/20 | 0.64 |
| ▸ | CSF1R | P07333 | 5/20 | 0.64 |
| ▸ | KDR | P35968 | 10/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177763 | 0.89 | PDGFRB (0.67) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL5177825 | 0.89 | PDGFRB (0.56) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL5177962 | 0.88 | PDGFRB (0.72) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL5178990 | 0.87 | PDGFRB (0.64) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL5179514 | 0.85 | PDGFRB (0.62) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL1097872 | 0.80 | PDGFRB (0.70) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL1098225 | 0.80 | PDGFRB (0.65) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL1098822 | 0.79 | PDGFRB (0.65) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL1098249 | 0.78 | PDGFRB (1.00) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL1097832 | 0.78 | PDGFRB (0.67) | PDGFRBFLT3FLT4CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |