Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 18/20 | 0.62 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178239 | 0.90 | CHEK2 (0.61) | CHEK2 | |
| SCHEMBL5176810 | 0.89 | CHEK2 (0.62) | CHEK2 | |
| SCHEMBL5177827 | 0.89 | CHEK2 (0.62) | CHEK2 | |
| SCHEMBL5179268 | 0.89 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL5186567 | 0.87 | CHEK2 (0.65) | CHEK2 | |
| SCHEMBL5179098 | 0.86 | CHEK2 (0.64) | CHEK2 | |
| SCHEMBL5178101 | 0.86 | CHEK2 (0.64) | CHEK2 | |
| SCHEMBL5176026 | 0.86 | CHEK2 (0.64) | CHEK2 | |
| SCHEMBL5178100 | 0.85 | CHEK2 (0.50) | CHEK2 | |
| SCHEMBL5178975 | 0.85 | CHEK2 (0.65) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-B1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5]-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-06 | — | — | EP | claimed |