Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 14/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | RAF1 | P04049 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13855380 | 0.88 | LCK (0.57) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374142 | 0.87 | LCK (0.61) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL27700550 | 0.82 | LCK (0.53) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374414 | 0.81 | CSF1R (0.53) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374312 | 0.80 | LCK (0.64) | LCKBRAFCSF1RKITKDR | |
| SCHEMBL373971 | 0.80 | LCK (0.66) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374728 | 0.79 | LCK (0.65) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374503 | 0.79 | LCK (0.67) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374492 | 0.78 | LCK (0.70) | LCKBRAFCSF1RKITRAF1 | |
| SCHEMBL374545 | 0.78 | LCK (0.68) | LCKBRAFCSF1RKITRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761505-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000420-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-01-05 | — | — | WO | disclosed |