Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826896 | 0.95 | CETP (0.34) | CETPMDM2 | |
| Hydrochloric Acid SCHEMBL1897529 | 0.95 | CETP (0.33) | CETPMDM2 | |
| SCHEMBL1901068 | 0.93 | CETP (0.35) | CETP | |
| Bicarbonate SCHEMBL5182760 | 0.86 | CETP (0.36) | CETPTACR1 | |
| Bicarbonate SCHEMBL5182373 | 0.85 | CETP (0.37) | CETPTACR1MDM2PSEN1PSEN2 | |
| Bicarbonate SCHEMBL5214022 | 0.85 | CETP (0.36) | CETPTACR1MDM2 | |
| SCHEMBL4829262 | 0.85 | CETP (0.35) | CETP | |
| Hydrochloric Acid SCHEMBL1901413 | 0.84 | CETP (0.35) | CETP | |
| Bicarbonate SCHEMBL5181521 | 0.83 | CETP (0.35) | CETPTACR1 | |
| SCHEMBL4829301 | 0.83 | CETP (0.35) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1533292-B1 | DIBENZYLAMINE COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC (JP) | 2007-02-14 | — | — | EP | claimed |