⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402099 | 1.00 | — | — | |
| SCHEMBL2364264 | 1.00 | — | — | |
| SCHEMBL15293505 | 0.76 | — | — | |
| SCHEMBL17028911 | 0.74 | — | — | |
| SCHEMBL24139829 | 0.70 | — | — | |
| SCHEMBL16414887 | 0.70 | — | — | |
| SCHEMBL6119374 | 0.70 | — | — | |
| SCHEMBL22343323 | 0.70 | — | — | |
| SCHEMBL4200121 | 0.70 | — | — | |
| SCHEMBL12424253 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111233751-B | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2021-02-02 | — | — | CN | claimed |
| CN-111233751-A | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2020-06-05 | — | — | CN | claimed |
| WO-2021262426-A9 | ADAMANTANE AMIDES AND THIOAMIDES FOR THE TREATMENT OF EBOLAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2022-03-17 | — | — | WO | disclosed |
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
| EP-3830080-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2021-06-09 | — | — | EP | disclosed |
| CN-112513024-A | TLR7/8 antagonists and uses thereof | 默克专利股份公司 | 2021-03-16 | — | — | CN | disclosed |
| US-10941134-B2 | AMPK-activating heterocyclic compounds and methods for using the same | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| CN-111233751-B | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111233751-B | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111233751-B | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111233751-A | Preparation method of 3, 3-difluoro-4-aminopiperidine compound and derivative thereof | 丽水绿氟科技有限公司 | 2020-06-05 | — | — | CN | disclosed |
| US-20130203987-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-8501765-B2 | Diazacarbazoles and methods of use | GENENTECH, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8501765-B2 | Diazacarbazoles and methods of use | GENENTECH, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| CN-102712640-A | Tricyclic heterocyclic compounds, compositions and methods of use thereof | HOFFMANN LA ROCHE | 2012-10-03 | — | — | CN | disclosed |
| US-20120028954-A1 | Substituted Pyridine, Pyridazine, Pyrazine And Pyrimidine Compounds And Methods For Using The Same | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| US-20110118230-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. | 2011-05-19 | — | — | US | disclosed |
| US-20110118230-A1 | DIAZACARBAZOLES AND METHODS OF USE | GENENTECH, INC. | 2011-05-19 | — | — | US | disclosed |