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Sugi Predict / Compounds / SCHEMBL5186183

SCHEMBL5186183

SCHEMBL5186183

CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(-c2ccoc2)cc1.CC(C)S(=O)(=O)N[C@H]1CN(C)C[C@@H]1c1ccc(-c2csc3ccccc23)cc1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GRIA2 P42262 20/20 0.57
▸ KCNH2 Q12809 14/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4956524 0.91 GRIA2 (0.67) GRIA2KCNH2
SCHEMBL4957419 0.86 GRIA2 (0.67) GRIA2KCNH2
SCHEMBL4957429 0.86 GRIA2 (0.67) GRIA2KCNH2
SCHEMBL4957409 0.86 GRIA2 (0.67) GRIA2KCNH2
SCHEMBL4955474 0.73 GRIA2 (1.00) GRIA2KCNH2
SCHEMBL4958423 0.72 GRIA2 (0.74) GRIA2KCNH2
SCHEMBL4957451 0.72 GRIA2 (1.00) GRIA2KCNH2
SCHEMBL5185510 0.72 GRIA2 (1.00) GRIA2KCNH2
SCHEMBL4957213 0.70 GRIA2 (0.70) GRIA2KCNH2
SCHEMBL5185436 0.69 GRIA2 (1.00) GRIA2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786769-A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2007-05-23 — — EP claimed
WO-2006015827-A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE GLAXO GROUP LIMITED (GB) 2006-02-16 — — WO claimed