Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4911091 | 0.89 | MAPT (0.60) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL5187132 | 0.85 | MAPT (0.52) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4922506 | 0.82 | MAPT (0.78) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4122958 | 0.80 | MAPT (1.00) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4920241 | 0.80 | MAPT (0.73) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL5175995 | 0.77 | MEN1 (0.59) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4917123 | 0.75 | KMT2A (0.74) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL5176732 | 0.74 | TSHR (0.66) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4924206 | 0.74 | MAPT (0.72) | MAPTMEN1KMT2ACASP3TRPV1 | |
| SCHEMBL4918746 | 0.73 | HPGD (0.74) | MAPTMEN1KMT2ACASP3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786422-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | Prosidion Limited (GB) | 2007-05-23 | — | — | EP | claimed |
| WO-2006018662-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | PROSIDION LIMITED (GB) | 2006-02-23 | — | — | WO | claimed |