Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304809 | 0.90 | CHEK1 (0.49) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL305566 | 0.81 | CHEK1 (0.53) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL305567 | 0.81 | CHEK1 (0.53) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL304790 | 0.81 | CHEK1 (0.53) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL10076322 | 0.80 | CHEK1 (0.54) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL6255798 | 0.80 | CHEK1 (0.52) | CHEK1CHEK2AKT1MEN1KMT2A | |
| SCHEMBL305231 | 0.79 | CHEK1 (0.52) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL305619 | 0.79 | CHEK1 (0.52) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL306082 | 0.79 | CHEK1 (0.52) | CHEK1CHEK2AKT1FECHKCNH2 | |
| SCHEMBL306083 | 0.79 | CHEK1 (0.52) | CHEK1CHEK2AKT1FECHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869020-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105262-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |