Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 16/20 | 0.77 |
| ▸ | EGFR | P00533 | 14/20 | 0.77 |
| ▸ | LCK | P06239 | 1/20 | 0.77 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.65 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708572 | 0.89 | ERBB2 (0.72) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL5568971 | 0.88 | ERBB2 (0.76) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL6957615 | 0.88 | ERBB2 (0.71) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL9973619 | 0.86 | ERBB2 (0.73) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL30125866 | 0.86 | ERBB2 (0.73) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL2989878 | 0.86 | ERBB2 (0.73) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL17845956 | 0.86 | ERBB2 (0.73) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL6980188 | 0.86 | ERBB2 (0.73) | ERBB2EGFRLCKAURKARPS6KB1 | |
| Hydrochloric Acid SCHEMBL17845945 | 0.85 | ERBB2 (0.72) | ERBB2EGFRLCKAURKARPS6KB1 | |
| Hydrochloric Acid SCHEMBL29793455 | 0.85 | ERBB2 (0.72) | ERBB2EGFRLCKAURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854789-B1 | QUINAZOLINE DERIVATIVE HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2013-10-09 | — | — | EP | disclosed |
| EP-1854789-A1 | QUINAZOLINE DERIVATIVE HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2007-11-14 | — | — | EP | disclosed |