Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5472858 | 0.93 | IGF1R (0.42) | IGF1R | |
| Trifluoroacetic Acid SCHEMBL5188565 | 0.72 | IGF1R (0.43) | IGF1R | |
| SCHEMBL2938589 | 0.72 | IGF1R (0.52) | IGF1RTAS2R8 | |
| SCHEMBL4884432 | 0.69 | IGF1R (0.58) | IGF1RTAS2R8 | |
| SCHEMBL4884448 | 0.69 | IGF1R (0.55) | IGF1RTAS2R8 | |
| SCHEMBL4889027 | 0.67 | IGF1R (0.60) | IGF1RTAS2R8 | |
| SCHEMBL1108960 | 0.67 | CYP2C9 (0.52) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3008275 | 0.66 | IGF1R (0.68) | IGF1RTAS2R8 | |
| SCHEMBL1100753 | 0.66 | CYP2C9 (0.51) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13039129 | 0.65 | IGF1R (0.67) | IGF1RTAS2R8CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773828-A1 | HETEROCYCLE -SUBSTITUTED CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010642-A1 | HETEROCYCLE-SUBSTITUTED CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-02-02 | — | — | WO | disclosed |