Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29826422 | 1.00 | TDP1 (0.56) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL4506549 | 0.87 | KDM4E (0.50) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL4521411 | 0.87 | KDM4E (0.50) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL490297 | 0.86 | KDM4E (0.58) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL31070288 | 0.85 | KMT2A (0.62) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL31070293 | 0.85 | MAPT (0.60) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL26563278 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL472707 | 0.83 | KMT2A (0.48) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL472705 | 0.82 | KMT2A (0.47) | ALDH1A1KDM4EHPGDMAPTHSD17B10 | |
| SCHEMBL969512 | 0.82 | CA12 (0.50) | MAPTGAAKMT2AMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833825-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069277-A1 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |