Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.84 |
| ▸ | INSR | P06213 | 6/20 | 0.84 |
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | BRD4 | O60885 | 7/20 | 0.61 |
| ▸ | NPM1 | P06748 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | BRD2 | P25440 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2508812 | 0.92 | ALK (0.79) | ALKINSRJAK2CYP3A4BRD4 | |
| SCHEMBL520919 | 0.91 | ALK (0.70) | ALKINSRJAK2CYP3A4BRD4 | |
| SCHEMBL519687 | 0.91 | ALK (1.00) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL16531842 | 0.90 | ALK (0.84) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL520301 | 0.87 | ALK (1.00) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL519686 | 0.86 | ALK (0.73) | ALKINSRJAK2CYP3A4BRD4 | |
| SCHEMBL520656 | 0.82 | ALK (0.84) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521941 | 0.82 | ALK (0.82) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL520981 | 0.82 | JAK2 (0.77) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL3469442 | 0.82 | JAK2 (0.77) | ALKINSRJAK2CYP3A4NPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | ALK 2/4885INSR 1738/4885JAK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.