Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.77 |
| ▸ | CDK1 | P06493 | 17/20 | 0.77 |
| ▸ | CCNE1 | P24864 | 17/20 | 0.77 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.77 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.77 |
| ▸ | CDK4 | P11802 | 3/20 | 0.77 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.77 |
| ▸ | CCND1 | P24385 | 3/20 | 0.77 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.77 |
| ▸ | FLT3 | P36888 | 4/20 | 0.75 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.64 |
| ▸ | CDK7 | P50613 | 1/20 | 0.64 |
| ▸ | CDK9 | P50750 | 1/20 | 0.64 |
| ▸ | CCNH | P51946 | 1/20 | 0.64 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195222 | 1.00 | CDK2 (0.77) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| Hydrochloric Acid SCHEMBL27560230 | 0.99 | CDK2 (0.75) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| Hydrochloric Acid SCHEMBL5627125 | 0.99 | CDK2 (0.75) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL5196111 | 0.94 | CDK2 (0.78) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL5196126 | 0.94 | CDK2 (0.78) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL5627382 | 0.89 | CDK2 (0.70) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL5627387 | 0.89 | CDK2 (0.70) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| Hydrochloric Acid SCHEMBL27557717 | 0.89 | CDK2 (0.69) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL6817897 | 0.87 | CDK1 (1.00) | CDK2CDK1CCNE1CCNE2CCNB2 | |
| SCHEMBL6817899 | 0.87 | CDK1 (1.00) | CDK2CDK1CCNE1CCNE2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183256-B1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2007-08-22 | — | — | EP | disclosed |
| EP-1183256-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071543-A1 | PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2000-11-30 | — | — | WO | disclosed |