Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 18/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 17/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388617 | 0.82 | HRH3 (0.60) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388906 | 0.81 | HRH3 (0.52) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388436 | 0.79 | HRH3 (0.59) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL387361 | 0.79 | HRH3 (0.60) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL385094 | 0.78 | HRH3 (0.57) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL390206 | 0.76 | HRH3 (0.55) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL5124762 | 0.76 | HRH3 (0.57) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL385666 | 0.76 | HRH3 (0.59) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL14378986 | 0.76 | HRH3 (0.59) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL385356 | 0.74 | HRH3 (0.58) | HRH3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613597-B1 | 6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2007-11-07 | — | — | EP | disclosed |