Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16498030 | 1.00 | MAPT (0.37) | MAPTKMT2ACYP2C19KCNN4HIF1A | |
| SCHEMBL5195703 | 1.00 | MAPT (0.37) | MAPTKMT2ACYP2C19KCNN4HIF1A | |
| SCHEMBL15668593 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL6036537 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL833033 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL15668595 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL30775651 | 0.83 | SSTR4 (0.36) | MAPTKMT2ACYP2C19KCNN4HIF1A | |
| SCHEMBL5427678 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL18649120 | 0.83 | KCNN4 (0.43) | KMT2AKCNN4CYP1A2HDAC3HDAC4 | |
| SCHEMBL23297726 | 0.77 | CYP1A2 (0.39) | MAPTKMT2ACYP2C19KCNN4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |