Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335981 | 0.80 | AAK1 (0.33) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL643632 | 0.79 | AAK1 (0.35) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL5345861 | 0.77 | AAK1 (0.35) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL24488616 | 0.76 | AAK1 (0.33) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL1486172 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL1486174 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL28520254 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL25384118 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL6843570 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 | |
| SCHEMBL1337447 | 0.76 | AAK1 (0.32) | AAK1HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831211-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS | Theravance, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006069125-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS | THERAVANCE, INC. (US) | 2006-06-29 | — | — | WO | disclosed |