Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.49 |
| ▸ | PDE4A | P27815 | 12/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549580 | 1.00 | PDE4B (0.49) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL5246847 | 0.89 | TP53 (0.56) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL3551575 | 0.88 | SMN1; SMN2 (0.49) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL3552383 | 0.88 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3546863 | 0.88 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3544153 | 0.88 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3550263 | 0.87 | PDE4A (0.47) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL3551471 | 0.87 | MAPT (0.49) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL3547020 | 0.87 | SMN1; SMN2 (0.47) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D | |
| SCHEMBL3555029 | 0.87 | SMN1; SMN2 (0.47) | PDE4BPDE4ASMN1; SMN2PDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |