Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415491 | 0.86 | KIT (0.47) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL720426 | 0.86 | AAK1 (0.44) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL858808 | 0.85 | KIT (0.46) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL416918 | 0.85 | KIT (0.46) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL7969382 | 0.84 | KIT (0.43) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL17435049 | 0.84 | KIT (0.43) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL859084 | 0.84 | KIT (0.50) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL878694 | 0.83 | KIT (0.47) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL10267300 | 0.83 | KIT (0.45) | KITNEK1AAK1RIPK1DYRK1A | |
| SCHEMBL415351 | 0.82 | NEK1 (0.47) | KITNEK1AAK1RIPK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893612-A1 | PYRROLO [2, 3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |