Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | VEGFA | P15692 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545649 | 0.94 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3548453 | 0.91 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3551708 | 0.86 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3551971 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5196595 | 0.84 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3551952 | 0.83 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3544974 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3546298 | 0.82 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4505908 | 0.81 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3542652 | 0.81 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |