Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548794 | 0.92 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3540908 | 0.90 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3544816 | 0.88 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3548834 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3550271 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3546697 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3541142 | 0.82 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5194306 | 0.81 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27600683 | 0.81 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL3543809 | 0.80 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |