Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | GCGR | P47871 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197308 | 0.89 | TEK (0.45) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5184613 | 0.87 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5199088 | 0.82 | TEK (0.45) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5185055 | 0.81 | TEK (0.48) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5196919 | 0.80 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5199659 | 0.79 | GCGR (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5197084 | 0.78 | TEK (0.46) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5197958 | 0.77 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11TEK | |
| SCHEMBL5197068 | 0.77 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5921871 | 0.76 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |