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SCHEMBL5197260

SCHEMBL5197260

COc1ccc(C2CC(=O)N(Cc3ccccc3Cl)C2)cc1OC1CCCC1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 15/20 0.79
▸ PDE4B Q07343 14/20 0.70
▸ PDE4C Q08493 10/20 0.70
▸ PDE4D Q08499 10/20 0.70
▸ LMNA P02545 2/20 0.51
▸ CYP3A4 P08684 2/20 0.50
▸ VEGFA P15692 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ CYP1A2 P05177 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ CREBBP Q92793 1/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ PDE5A O76074 1/20 0.50
▸ TNF P01375 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ BLM P54132 1/20 0.50
▸ PDE1A P54750 1/20 0.50
▸ PDE1B Q01064 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3545707 1.00 PDE4A (0.79) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3538653 1.00 PDE4A (0.79) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3546861 0.90 PDE4A (0.77) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3547932 0.90 PDE4A (0.77) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL5790986 0.90 PDE4A (0.77) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL7363058 0.89 PDE4A (0.76) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3545145 0.89 PDE4A (0.76) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL5793912 0.89 PDE4A (0.76) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3549106 0.89 PDE4A (0.76) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL3541761 0.88 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613590-A2 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceutical Corporation (US) 2006-01-11 — — EP claimed
WO-2004094375-A2 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2004-11-04 — — WO claimed
EP-1435944-A1 4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES Memory Pharmaceutical Corporation (US) 2004-07-14 — — EP claimed
WO-2003032981-A1 4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES MEMORY PHARMACEUTICALS CORPORATION (US) 2003-04-24 — — WO claimed
EP-1802615-A1 PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceuticals Corporation (US) 2007-07-04 — — EP disclosed
WO-2006044955-A1 PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2006-04-27 — — WO disclosed
EP-1613590-A2 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS Memory Pharmaceutical Corporation (US) 2006-01-11 — — EP disclosed
WO-2004094375-A2 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS MEMORY PHARMACEUTICALS CORPORATION (US) 2004-11-04 — — WO disclosed
EP-1435944-A1 4(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES Memory Pharmaceutical Corporation (US) 2004-07-14 — — EP disclosed
WO-2003032981-A1 4-(4-ALKOXY-3-HYDROXYPHENYL)-2-PYRROLIDONE DERIVATIVES AS PDE-4 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL SYNDROMES MEMORY PHARMACEUTICALS CORPORATION (US) 2003-04-24 — — WO disclosed