Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.70 |
| ▸ | RAF1 | P04049 | 3/20 | 0.70 |
| ▸ | GCGR | P47871 | 12/20 | 0.68 |
| ▸ | TEK | Q02763 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791925 | 0.88 | GCGR (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL17002223 | 0.87 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5198574 | 0.87 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5184633 | 0.86 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5197475 | 0.85 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8791626 | 0.85 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6468726 | 0.84 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6468355 | 0.84 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6961281 | 0.82 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5921854 | 0.82 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173048-A1 | Imidazole derivatives | GRM2, GRM1, GRIN2C | MAPK14 2620/4885MAPK13 2722/4885MAPK12 2936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.