Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549287 | 1.00 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL5756596 | 0.89 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3544460 | 0.83 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DCYP2C19 | |
| SCHEMBL3547855 | 0.83 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3552710 | 0.82 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5759950 | 0.82 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3554673 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCLK1 | |
| SCHEMBL3550381 | 0.82 | CLK1 (0.41) | PDE4APDE4BPDE4CPDE4DHCRTR1 | |
| SCHEMBL5196945 | 0.82 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCLK1 | |
| SCHEMBL4467048 | 0.80 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |