Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293342 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7594974 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL2029987 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL2029661 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL2031639 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL5198220 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL11771639 | 0.83 | DPP4 (0.33) | DPP4DPP8DPP9 | |
| SCHEMBL6858335 | 0.82 | CYP2D6 (0.60) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL200243 | 0.82 | — | — | |
| SCHEMBL2024894 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276491-B9 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | UNIV PENNSYLVANIA (US) | 2007-02-28 | — | — | EP | claimed |
| EP-1276491-B1 | TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM | UNIV PENNSYLVANIA (US) | 2006-09-20 | — | — | EP | claimed |