Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10819124 | 0.98 | PDGFRB (0.49) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| Hydrochloric Acid SCHEMBL11071908 | 0.98 | PDGFRB (0.49) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| Methyl Alcohol SCHEMBL10773137 | 0.95 | PDGFRB (0.50) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL29350099 | 0.81 | NPC1 (0.65) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL150476 | 0.81 | NPC1 (0.65) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL842549 | 0.79 | CHRNB4 (0.31) | — | |
| SCHEMBL13156520 | 0.77 | NPC1 (0.60) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL12532559 | 0.77 | NPC1 (0.60) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL13156510 | 0.77 | NPC1 (0.60) | PDGFRBPDGFRAALDH1A1NPC1POLB | |
| SCHEMBL18700662 | 0.77 | NPC1 (0.60) | PDGFRBPDGFRAALDH1A1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280530-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-05 | — | — | EP | claimed |
| WO-2002083141-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-24 | — | — | WO | claimed |
| WO-2001087308-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-22 | — | — | WO | claimed |
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | claimed |
| EP-0111990-B1 | HYPOTENSIVE AGENTS | ELI LILLY AND COMPANY (US) | 1987-10-07 | — | — | EP | claimed |
| EP-0013787-B1 | OCTAHYDRO PYRAZOLO (3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | claimed |
| EP-1841752-A1 | 3,4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2007-10-10 | — | — | EP | disclosed |
| EP-1740610-A2 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006077487-A1 | 3,4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2006-07-27 | — | — | WO | disclosed |
| EP-1683790-A1 | 3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005105839-A2 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-11-10 | — | — | WO | disclosed |
| EP-1591455-A1 | Essential tremor diagnostic and treatment | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-11-02 | — | — | EP | disclosed |
| EP-1280530-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-05 | — | — | EP | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| EP-0050881-A1 | Octahydro quinoline derivatives | ELI LILLY AND COMPANY (US) | 1982-05-05 | — | — | EP | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0013787-A1 | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |