Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.79 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.79 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL27684484 | 0.89 | CYP1A2 (0.91) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL28814927 | 0.89 | CYP2A6 (1.00) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL49861 | 0.89 | CYP2A6 (1.00) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL29736830 | 0.89 | CYP2A6 (1.00) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| Formaldehyde SCHEMBL1056088 | 0.87 | TSHR (0.86) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL9614419 | 0.87 | CYP2A6 (0.95) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL28536959 | 0.87 | CYP2A6 (0.95) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL2810486 | 0.87 | CYP2A6 (0.95) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| SCHEMBL31498531 | 0.87 | CYP2A6 (0.95) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 | |
| Methane SCHEMBL16097895 | 0.87 | CYP2A6 (0.95) | TSHRCYP2A6CYP1A2HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1172409-B1 | THERMOPLASTIC RESIN COMPOSITION AND PROCESS FOR PRODUCING THE SAME | KANEKA CORP (JP) | 2007-02-21 | — | — | EP | disclosed |
| US-7138453-B1 | Thermoplastic resin composition and process for preparing the same | KANEKA CORPORATION (JP) | 2006-11-21 | — | — | US | disclosed |
| EP-1172409-A1 | THERMOPLASTIC RESIN COMPOSITION AND PROCESS FOR PRODUCING THE SAME | KANEKA CORPORATION (JP) | 2002-01-16 | — | — | EP | disclosed |