Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225527 | 0.86 | IDO1 (0.53) | PDE2AIDO1HTR2AHTR2CHTR2B | |
| SCHEMBL3460243 | 0.83 | PDE2A (0.44) | PDE2AIDO1HTR2AHTR2CHTR2B | |
| SCHEMBL3466401 | 0.83 | PDE2A (0.44) | PDE2AIDO1HTR2AHTR2CHTR2B | |
| SCHEMBL18896392 | 0.81 | IDO1 (0.49) | PDE2AIDO1HTR2AHTR2CHTR2B | |
| SCHEMBL14402603 | 0.81 | PDE2A (0.48) | PDE2AIDO1CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL13849947 | 0.81 | PDE2A (0.48) | PDE2AIDO1CYP3A4CYP2D6SLC6A4 | |
| SCHEMBL1552832 | 0.80 | IDO1 (0.47) | PDE2AIDO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1552834 | 0.80 | IDO1 (0.47) | PDE2AIDO1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL14402710 | 0.79 | IDO1 (0.46) | PDE2AIDO1HTR2AHTR2CHTR2B | |
| SCHEMBL439644 | 0.78 | DPP4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844026-A2 | MORPHOLINES AS 5HT2C AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006077025-A2 | MORPHOLINES AS 5HT2C AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-27 | — | — | WO | disclosed |