Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199146 | 0.86 | MAPK14 (0.40) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5197480 | 0.84 | MAPK14 (0.38) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5199024 | 0.82 | MAPK14 (0.44) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5199808 | 0.82 | OPRL1 (0.38) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5194594 | 0.81 | MAPK14 (0.36) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5197184 | 0.81 | MAPK14 (0.43) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5184567 | 0.81 | NPSR1 (0.39) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5200392 | 0.78 | MAPK14 (0.41) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5198712 | 0.78 | TEK (0.48) | GCGRMAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5184902 | 0.77 | CYP19A1 (0.43) | GCGRMAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | claimed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | claimed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | claimed |
| CN-101155796-A | Imidazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173048-A1 | Imidazole derivatives | GRM2, GRM1, GRIN2C | GCGR 271/4885MAPK14 2620/4885MAPK11 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.