Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200758 | 0.89 | CYSLTR1 (0.44) | CYSLTR1GRM2MRGPRX4CYSLTR2 | |
| SCHEMBL3862884 | 0.89 | CYSLTR1 (0.40) | CYSLTR1GRM2MRGPRX4CYSLTR2 | |
| SCHEMBL5202571 | 0.85 | CYSLTR1 (0.48) | CYSLTR1GRM2MRGPRX4CYSLTR2 | |
| SCHEMBL481338 | 0.85 | CYSLTR1 (0.59) | CYSLTR1GRM2CYSLTR2 | |
| SCHEMBL27686392 | 0.84 | CYSLTR1 (0.47) | CYSLTR1GRM2MRGPRX4CYSLTR2 | |
| SCHEMBL481082 | 0.79 | CYSLTR1 (0.56) | CYSLTR1GRM2CYSLTR2 | |
| SCHEMBL481648 | 0.77 | CYSLTR1 (0.56) | CYSLTR1GRM2CYSLTR2 | |
| SCHEMBL481374 | 0.77 | CYSLTR1 (0.56) | CYSLTR1GRM2CYSLTR2 | |
| SCHEMBL13645726 | 0.75 | CYSLTR1 (0.63) | CYSLTR1GRM2MRGPRX4CYSLTR2 | |
| SCHEMBL480843 | 0.75 | CYSLTR1 (0.60) | CYSLTR1GRM2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817301-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057870-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |