Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15057161 | 0.80 | POLB (0.49) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL24680127 | 0.79 | POLB (0.41) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL4897646 | 0.79 | POLB (0.41) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL20972176 | 0.79 | POLB (0.41) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL17949442 | 0.79 | POLB (0.41) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL24908590 | 0.76 | POLB (0.39) | POLBALDH1A1MAPTSMN1; SMN2HCAR2 | |
| SCHEMBL27938280 | 0.75 | KDM4E (0.42) | POLBALDH1A1MAPTKDM4E | |
| SCHEMBL24679025 | 0.75 | POLB (0.38) | POLBALDH1A1MAPTSMN1; SMN2PDE10A | |
| SCHEMBL15057356 | 0.75 | POLB (0.44) | POLBALDH1A1MAPTSMN1; SMN2PDE10A | |
| SCHEMBL25331964 | 0.72 | POLB (0.45) | POLBALDH1A1MAPTSMN1; SMN2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858854-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094639-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |