Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.68 |
| ▸ | INSR | P06213 | 14/20 | 0.68 |
| ▸ | NPM1 | P06748 | 11/20 | 0.68 |
| ▸ | IGF1R | P08069 | 4/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | ERN1 | O75460 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FYN | P06241 | 2/20 | 0.55 |
| ▸ | FES | P07332 | 2/20 | 0.55 |
| ▸ | YES1 | P07947 | 2/20 | 0.55 |
| ▸ | HCK | P08631 | 2/20 | 0.55 |
| ▸ | ROS1 | P08922 | 2/20 | 0.55 |
| ▸ | FER | P16591 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519150 | 0.94 | ALK (0.78) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL520672 | 0.89 | ALK (0.85) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL519737 | 0.86 | ALK (0.81) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL519890 | 0.86 | ALK (0.80) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL518909 | 0.86 | ALK (0.85) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL520519 | 0.86 | ALK (0.83) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL521341 | 0.84 | ALK (0.72) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL16530443 | 0.84 | ALK (0.71) | ALKINSRNPM1JAK2KCNH2 | |
| SCHEMBL520286 | 0.83 | ALK (0.80) | ALKINSRNPM1IGF1RJAK2 | |
| SCHEMBL521066 | 0.83 | ALK (0.83) | ALKINSRNPM1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | claimed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | ALK 2/4885INSR 1738/4885NPM1 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.