Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157575 | 0.87 | GRM2 (0.72) | GRM2CYSLTR1CYSLTR2MEN1TSHR | |
| SCHEMBL5201693 | 0.79 | GRM2 (0.52) | GRM2CYSLTR1CYSLTR2MEN1CYP1A2 | |
| SCHEMBL3174993 | 0.76 | GRM2 (0.68) | GRM2CYSLTR1CYSLTR2MEN1TSHR | |
| SCHEMBL3166581 | 0.73 | GRM2 (0.73) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL5199297 | 0.73 | CYSLTR1 (0.50) | GRM2CYSLTR1CYSLTR2MEN1CYP1A2 | |
| SCHEMBL3166817 | 0.73 | GRM2 (0.73) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL5200187 | 0.72 | MEN1 (0.51) | GRM2CYSLTR1CYSLTR2MEN1CYP1A2 | |
| SCHEMBL5200521 | 0.72 | CYSLTR1 (0.58) | GRM2CYSLTR1CYSLTR2MEN1CYP1A2 | |
| SCHEMBL12993380 | 0.71 | GRM2 (0.72) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL6245759 | 0.71 | CYSLTR1 (0.59) | GRM2CYSLTR1CYSLTR2MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |