Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156314 | 0.82 | MEN1 (0.62) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL10170602 | 0.82 | MEN1 (0.62) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL3749117 | 0.82 | MEN1 (0.62) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL6249125 | 0.81 | CYP3A4 (0.55) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL350056 | 0.79 | TSHR (0.53) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL11770993 | 0.79 | TSHR (0.53) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL7475129 | 0.79 | TSHR (0.53) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL30692971 | 0.79 | MEN1 (0.58) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL5676207 | 0.79 | KMT2A (0.55) | MEN1MAPTKMT2ATSHRALDH1A1 | |
| SCHEMBL964066 | 0.79 | KMT2A (0.55) | MEN1MAPTKMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819672-A1 | INDOLE-2-CARBOXYLIC ACID AMIDES | Prosidion Limited (GB) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006056815-A1 | INDOLE-2-CARBOXYLIC ACID AMIDES | PROSIDION LIMITED (GB) | 2006-06-01 | — | — | WO | disclosed |
| EP-0296597-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5061795-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1991-10-29 | — | — | US | disclosed |
| US-4939255-A | Hexa-cyclic camptothecin derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0296597-A2 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |