SCHEMBL5201039

SCHEMBL5201039

O=C(NC1CC1)N1CCCC1

nearest known ligand 0.83

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.83
POLB P06746 4/20 0.58
HSD17B10 Q99714 1/20 0.58
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.53
MAPK1 P28482 1/20 0.53
DPP7 Q9UHL4 1/20 0.53
PKM P14618 1/20 0.51
TSHR P16473 1/20 0.51
HSD11B1 P28845 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3651038 0.98 HTT (0.80) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8393313 0.98 HTT (0.88) HTTPOLBHSD17B10KDM4EALDH1A1
Hydrochloric Acid SCHEMBL3649129 0.96 HTT (0.84) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL4560498 0.95 HTT (0.76) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8391614 0.93 HTT (0.96) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8396161 0.93 HTT (0.88) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8393766 0.91 HTT (0.92) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL13380 0.91 HTT (1.00) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8392088 0.91 HTT (1.00) HTTPOLBHSD17B10KDM4EALDH1A1
SCHEMBL8396675 0.91 HTT (1.00) HTTPOLBHSD17B10KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3939979-A1 JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE Shanghai Synergy Pharmaceutical Sciences Co., Ltd (CN) 2022-01-19 EP disclosed
WO-2020182159-A1 JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE 上海华汇拓医药科技有限公司 2020-09-17 WO disclosed
WO-2016034134-A1 HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-03-10 WO disclosed
EP-1748999-A1 IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION AstraZeneca AB (SE) 2007-02-07 EP disclosed
WO-2005075461-A1 IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION ASTRAZENECA AB (SE) 2005-08-18 WO disclosed
US-5864043-A CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST KARL THOMAE GMBH (DE) 1999-01-26 US disclosed
US-5541229-A ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-07-30 US disclosed