Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.59 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | SENP5 | Q96HI0 | 14/20 | 0.39 |
| ▸ | SENP2 | Q9HC62 | 14/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 14/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485016 | 0.81 | CXCR2 (0.58) | CXCR2KDM4EALDH1A1 | |
| SCHEMBL485651 | 0.80 | CXCR2 (0.73) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485308 | 0.76 | CXCR2 (0.64) | CXCR2KDM4EALDH1A1 | |
| SCHEMBL485276 | 0.76 | CXCR2 (0.61) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL3928722 | 0.75 | CXCR2 (1.00) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485460 | 0.74 | CXCR2 (0.62) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485458 | 0.74 | CXCR2 (0.64) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL484955 | 0.72 | CXCR2 (0.65) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485388 | 0.71 | CXCR2 (0.57) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485074 | 0.67 | CXCR2 (0.52) | CXCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | Sanofi-Aventis Deutschland GmbH (DE) | 2007-09-26 | — | — | EP | claimed |
| WO-2006069656-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-06 | — | — | WO | claimed |
| EP-1836158-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | Sanofi-Aventis Deutschland GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069656-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-06 | — | — | WO | disclosed |